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El tadalafilo es un frmaco utilizado para tratar la disfuncin erctil (DE). Cita requerida, ha sido desarrollado por la firma de biotecnologa, iCOS y comercializado por, eli Lilly and Company bajo el nombre de, cialis. Frmaco anlogo al sildenafilo, comercializado con el nombre. Viagra, se diferencia de este ltimo en que que es cialis el efecto del tadalafilo es ms prolongado, llegando a que es cialis ser funcional hasta las 36 horas, mientras que el Sildenafil surte efecto por 4 5 horas. Por este motivo se lo llam "la pldora del fin de semana". Cita requerida ndice, la aprobacin del Viagra por la FDA, el 27 de marzo de 1998, fue un innovador evento comercial para el tratamiento de la disfuncin erctil, con ventas que superan los mil millones dlares. Posteriormente, la FDA aprob Levitra ( vardenafilo el 19 de agosto de 2003, y Cialis (tadalafilo el 21 de noviembre de 2003. El tadalafilo es descubierto por Glaxo Wellcome (ahora. GlaxoSmithKline que es cialis ) en virtud de una asociacin entre Glaxo e icos para desarrollar nuevos medicamentos que se inici en agosto de 1991. 2 3, en 1993, el Bothell, Washington, compaa de biotecnologa icos Corporation comenz a estudiar el compuesto IC351, un inhibidor de la enzima PDE-5. En que es cialis 1994, los cientficos de Pfizer descubren que el sildefanilo citrato de sildefanil, que tambin inhibe la PDE5, caus la ereccin del pene en hombres que participan en un estudio clnico de un medicamento para el corazn. Aunque los cientficos de icos no hicieron pruebas del compuesto IC351 para el tratamiento de la DE, reconocieron su utilidad potencial para el tratamiento de este trastorno. En 1994, icos recibi una patente para IC351 (estructuralmente similar al sildenafilo y al vardenafilo y al ao siguiente inici los ensayos clnicos de fase. En 1997, se comenzaron los ensayos clnicos de fase 2 en hombres con. En la fase 3 se hicieron ensayos que apoyaron la aprobacin del medicamento por la FDA. Aunque Glaxo tena un acuerdo con icos para compartir los beneficios 50/50 de frmacos derivados de la asociacin, dej que venciera el acuerdo en 1996 alegando que los medicamentos desarrollados no estaban en los principales mercados de la compaa. 4, en 1998, icos Corporation y Eli Lilly and Company Lilly icos formaron LLC, una empresa conjunta para desarrollar y comercializar el tadalafilo como un tratamiento para la disfuncin erctil. Dos aos despus, Lilly icos, LLC, present una solicitud de autorizacin de nuevo frmaco a la FDA relativa a IC351 bajo el nombre genrico tadalafilo y el nombre comercial Cialis. En mayo de 2002, Lilly icos inform a la Asociacin Americana de Urologa que las pruebas de ensayo clnico demostraron que Cialis es eficaz por hasta 36 horas, y un ao despus, la FDA aprob el tadalafilo. Una ventaja que tiene Cialis sobre Viagra y Levitra es su vida media.5-hora (Cialis puede trabajar hasta 36 horas, despus de lo cual queda aproximadamente el 25 por ciento de la dosis absorbida en el cuerpo en comparacin con la media de cuatro. 5, en 2007, Eli Lilly and Company compr icos Corporation por 2,3 millones de dlares. Como resultado, Cialis qued como propiedad de Eli Lilly, que cerr las operaciones de icos, poniendo fin a la empresa conjunta y despidiendo a la mayora de los aproximadamente 500 empleados de icos, a excepcin de 127 empleados de la instalacin de biolgicos, que posteriormente. Las personas de apellido "Cialis" se opusieron a que Eli Lilly and Company utilizara esta marca, pero la compaa mantuvo que el nombre comercial no se relacionaba con el apellido. 6 Descripcin editar El tadalafilo es un frmaco inhibidor de la enzima fosfodiesterasa tipo 5 (PDE-5 encargada de desactivar al vasodilatador xido ntrico, cita requerida que actualmente se comercializa en forma de comprimidos bajo el nombre comercial de Cialis. Tambin ha sido recientemente aprobado para el tratamiento de la hipertensin arterial pulmonar, y ha sido utilizado para otras condiciones. Cita requerida Inicialmente fue desarrollado por icos Corporation, y luego nuevamente desarrollado y comercializado en todo el mundo por Lilly icos LLC, la "joint venture" de icos Corporation y Eli Lilly and Company. Los comprimidos de LA clave comercializados en Repblica Dominicana y Nicaragua, son de color rojo en forma de almendra. Los comprimidos de Cialis, que es cialis de 5mg, 10mg y 20mg de dosis, son de color amarillo recubiertos con una pelcula y en forma de almendra. 7 La dosis aprobada para la hipertensin arterial pulmonar es de 20mg y se comercializa bajo la marca Adcirca 8 En diciembre de 2003, la Agencia de administracin de alimentos y medicamentos aprob el Cialis para la venta en los Estados Unidos como el tercer. Cita requerida La eficacia del taladafilo persiste durante 36 horas, por lo que se ha ganado el apodo de "la pldora de fin de semana".

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